Short description of each consortium

Central to this proposal are seven large well-established consortia. The main focus of these consortia has been to identify individuals with an increased risk of being diagnosed with breast, ovarian or prostate cancer. The emerging data clearly show that the effects of most individual genetic variants on risk will be small (16-18). This, coupled with the very large number of genetic loci to evaluate (and the even larger number of interactions) implies that very large sample sizes (>10,000 cases and matched controls) are needed to identify most associations (19), and even larger numbers are required to provide an accurate evaluation of interactions between genes and lifestyle risk factors (20).

The Breast Cancer Association Consortium (BCAC), Ovarian Cancer Association Consortium (OCAC) and PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations in the genome (PRACTICAL) are the largest consortia conducting association studies world-wide and are therefore uniquely placed to evaluate genetic susceptibility. Similarly, the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) in combination with the International BRCA1/2 Carrier Cohort Study (IBCCS) is the largest study of genetic modifiers for BRCA1 and BRCA2.

Consortia Responsible partner
The Breast Cancer Association Consortium (BCAC) University of Cambridge (UCAM), Great Britain
Ovarian Cancer Association Consortium (OCAC) University of Cambridge (UCAM), Great Britain
PRostate cancer AssoCiation group To
Investigate Cancer Associated aLterations in
the genome (PRACTICAL)
The Institute of Cancer Research (ICR), Great Britain
Consortium of Investigators of Modifiers of
BRCA1/2 (CIMBA)
University of Cambridge (UCAM), Great Britain
International BRCA1/2 Carrier Cohort Study (IBCCS) Vereniging Het Nederlands Kanker Instituut
(NKI), The Netherlands
Nordic Breast Cancer Array Consortium (NBAC) University of Lund (LU), Sweden
TRANSBIG The Breast International Group (BIG), Belgium

Additional information